TUT7 antibody
Product Specifications
Background
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly (A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299) . Involved in microRNA (miRNA) -induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299) . Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7) . Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984) . Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.
Synonyms
Terminal uridylyltransferase 7 (TUTase 7) |Zinc finger CCHC domain-containing protein 6|TUT7|HS2|KIAA1711|ZCCHC6
Gene ID
79670
UniProt
Q5VYS8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Zinc finger, CCHC domain containing 6
Target
TUT7
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:500-1:5000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
171 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP
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