ZC3HC1 antibody
Product Specifications
Background
Essential component of an SCF-type E3 ligase complex, SCF (NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1) . Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF (NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
Synonyms
Zinc finger C3HC-type protein 1|Nuclear-interacting partner of ALK (hNIPA) |Nuclear-interacting partner of anaplastic lymphoma kinase|ZC3HC1|NIPA
Gene ID
51530
UniProt
Q86WB0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Zinc finger, C3HC-type containing 1
Target
ZC3HC1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
55 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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