YTHDF1 antibody
Product Specifications
Background
Specifically recognizes and binds N6-methyladenosine (m6A) -containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451) . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625) . Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440) .
Synonyms
YTH domain-containing family protein 1 (DF1) |Dermatomyositis associated with cancer putative autoantigen 1 (DACA-1) |YTHDF1|C20orf21
Gene ID
54915
UniProt
Q9BYJ9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
YTH domain family, member 1
Target
YTHDF1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
62 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP
Immunogen Sequence
133-349aa
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