XRN2 antibody
Product Specifications
Background
Possesses 5'->3' exoribonuclease activity (By similarity) . May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224) .
Synonyms
5'-3' exoribonuclease 2|DHM1-like protein (DHP protein) |XRN2
Gene ID
22803
UniProt
Q9H0D6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
5'-3' exoribonuclease 2
Target
XRN2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
108 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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