ERCC5 antibody
Product Specifications
Background
The human genes correcting DNA repair defects are termed excision-repair cross-complementing or ERCC genes. The ERCC5 gene corrects the excision repair deficiency of Chinese hamster ovary cell line UV135 of complementation group 5. The human ERCC5 gene product is a structure-specific endonuclease required for making the 3-prime incision during DNA nucleotide excision-repair (NER) . It also plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light [PMID:22815677].
Synonyms
DNA excision repair protein ERCC-5|DNA repair protein complementing XP-G cells|Xeroderma pigmentosum group G-complementing protein|ERCC5|ERCM2|XPG|XPGC
UniProt
P28715
Host
Rabbit
Reactivity
Human
Immunogen
Excision repair cross-complementing rodent repair deficiency, complementation group 5
Target
ERCC5
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IF: 1:20-1:200; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
200 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP
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