WWP1 antibody
Product Specifications
Background
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
Synonyms
NEDD4-like E3 ubiquitin-protein ligase WWP1|Atrophin-1-interacting protein 5 (AIP5)|HECT-type E3 ubiquitin transferase WWP1|TGIF-interacting ubiquitin ligase 1 (Tiul1)|WW domain-containing protein 1|WWP1
Gene ID
11059
UniProt
Q9H0M0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
WW domain containing E3 ubiquitin protein ligase 1
Target
WWP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP, IHC, IF
Field of Research
Epigenetics, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
90-110 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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