WTAP antibody
Product Specifications
Background
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863) . Acts as a mRNA splicing regulator (PubMed:12444081) . Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532) . Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724) .
Synonyms
Pre-mRNA-splicing regulator WTAP|Female-lethal (2) D homolog (hFL (2) D) |WT1-associated protein|Wilms tumor 1-associating protein|WTAP|KIAA0105
Gene ID
9589
UniProt
Q15007
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Wilms tumor 1 associated protein
Target
WTAP
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC
Field of Research
Epigenetics
Purification
Protein A+G purification
Dilution
WB: 1:1000-1:10000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
49 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
9D4
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
1-150aa
Curated Selection
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