WTAP antibody
Product Specifications
Background
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724).
Synonyms
Pre-mRNA-splicing regulator WTAP|Female-lethal(2)D homolog (hFL(2)D)|WT1-associated protein|Wilms tumor 1-associating protein|WTAP|KIAA0105
Gene ID
9589
UniProt
Q15007
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Wilms tumor 1 associated protein
Target
WTAP
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IP, WB
Field of Research
Epigenetics
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
55 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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