WRN antibody
Product Specifications
Background
Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity) . Plays a role in double-strand break repair after gamma-irradiation.
Synonyms
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN|DNA helicase, RecQ-like type 3|RecQ protein-like 2|Werner syndrome protein|WRN|RECQ3|RECQL2
Gene ID
7486
UniProt
Q14191
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Werner syndrome, RecQ helicase-like
Target
WRN
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
162-200 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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