WRAP53 antibody

Product Specifications

Background

Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs) . The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.

Synonyms

Gene ID

55135

UniProt

Q9BUR4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

WD repeat containing, antisense to TP53

Target

WRAP53

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB, IHC, IP

Field of Research

Metabolism

Purification

Immunogen affinity purified

Dilution

WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:1000

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

72 kDa

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB, IHC, IP

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