WEE2 antibody
Product Specifications
Background
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle(GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation(By similarity).
Synonyms
Wee1-like protein kinase 2|Wee1-like protein kinase 1B|Wee1B kinase|WEE2|WEE1B
Gene ID
494551
UniProt
P0C1S8
Host
Rabbit
Reactivity
Human
Immunogen
WEE1 homolog 2(S. pombe)
Target
WEE2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Developmental biology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
63 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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