WEE2 antibody
Product Specifications
Background
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity) .
Synonyms
Wee1-like protein kinase 2|Wee1-like protein kinase 1B|Wee1B kinase|WEE2|WEE1B
Gene ID
494551
UniProt
P0C1S8
Host
Rabbit
Reactivity
Human
Immunogen
WEE1 homolog 2 (S. pombe)
Target
WEE2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Developmental biology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
63 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Immunogen Sequence
Peptide
Curated Selection
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