VWF, VWFpp antibody
Product Specifications
Background
Von Willebrand factor (vWF) is a large multimeric glycoprotein that is crucial to the hemostasis process. It supports platelet adhesion and carries factor VIII (FVIII) . Deficiency of vWF results in von Willebrand disease (vWD), a common inherited bleeding disorder. The pre-pro-vWF is comprised of 2,813 amino acids (aa) which encompass a 22-aa signal peptide, a 741-aa large propeptide (vWF propeptide, vWFpp, also called von Willebrand antigen II) and 2,050 aa making up the mature vWF. The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules. This antibody raised against the N-terminal region of pre-pro-vWF recognizes von Willebrand antigen 2 (75-83 kDa) and pro-vWF (309-320 kDa) .
Synonyms
Von Willebrand factor (vWF) |von Willebrand antigen 2 Alternative names: von Willebrand antigen II|VWF|F8VWF
UniProt
P04275
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Von Willebrand factor
Target
VWF, VWFpp
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Immunology, Cardiovascular
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IHC: 1:100-1:400
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
75 kDa, 309 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Curated Selection
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