VPS8 antibody
Product Specifications
Background
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290) . Functions predominantly in APPL1-containing endosomes (PubMed:25266290) .
Synonyms
Vacuolar protein sorting-associated protein 8 homolog|VPS8|KIAA0804
Gene ID
23355
UniProt
Q8N3P4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Vacuolar protein sorting 8 homolog
Target
VPS8
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF,IP
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:2000; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
151 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IP
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