SLC18A2 antibody

VMAT2 is a vesicular monoamine transporter that is responsible for the uptake and storage of monoamines (dopaine, norepinephrine, epinephrine, histamine and serotonin) in neurons, endocrine cells, and tumors deriving from these cells. Histamine-producing endocrine tumors (gastric carcinoids) expressed VMAT2 almost exclusively, thus VMAT2 is useful in classification of neuroendocrine tumors. Reduced expression of VMAT2 has often been observed in Parkinson’s diseased (PD) brain, and detection of VMAT2 can be used to reflect the dopamine neuron loss and predict the disease process. VMAT2 migrated as a major band of 65-75 kDa and a minor band of 55-60 kDa, representing the glycosylated form and native form.