USP9X antibody
Product Specifications
Background
Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'-and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Involved in axonal growth and neuronal cell migration.
Synonyms
Probable ubiquitin carboxyl-terminal hydrolase FAF-X|Deubiquitinating enzyme FAF-X|Fat facets in mammals (hFAM)|Fat facets protein-related, X-linked|Ubiquitin thioesterase FAF-X|Ubiquitin-specific protease 9, X chromosome|Ubiquitin-specific-processing protease FAF-X|USP9X|DFFRX|FAM|USP9
Gene ID
8239
UniProt
Q93008
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
ubiquitin specific peptidase 9, X-linked
Target
USP9X
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC, IP
Field of Research
Epigenetics, Cell Division and Proliferation, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IF: 1:10-1:100; IHC: 1:20-1:200; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
260-290 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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