USP18 antibody
Product Specifications
Background
Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. Isoform 2: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins (PubMed:22170061) .
Synonyms
Ubl carboxyl-terminal hydrolase 18|43 kDa ISG15-specific protease (hUBP43) |ISG15-specific-processing protease|Ubl thioesterase 18|USP18|ISG43
Gene ID
11274
UniProt
Q9UMW8
Host
Rabbit
Reactivity
Human
Immunogen
Ubiquitin specific peptidase 18
Target
USP18
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70 kDa, 43 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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