PLAU antibody
Product Specifications
Background
PLAU (Urokinase-type plasminogen activator) is also named as uPA and belongs to the peptidase S1 family.UPA initiates a proteolytic cascade, which degrades extracellular matrix during tissue growth and remodelling.The secreted proform of UPA is activated after binding to a specific high affinity cell surface receptor. Secreted UPA is exposed to rapid inactivation in the pericellular space by plasminogen activator inhibitor-1 (PAI-1), which is stored in the extracellular matrix bound to vitronectin (PMID:9665342) .It has 2 isoforms produced by alternative splicing.Defects in PLAU are the cause of Quebec platelet disorder (QPD) .
Synonyms
Urokinase-type plasminogen activator (U-plasminogen activator, uPA) |Urokinase-type plasminogen activator long chain A|Urokinase-type plasminogen activator short chain A|Urokinase-type plasminogen activator chain B|PLAU
Gene ID
5328
UniProt
P00749
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Plasminogen activator, urokinase
Target
PLAU
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP, IF
Field of Research
Immunology, Cardiovascular, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC:1:20-1:200; IF: 1:20-1:200; IP: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
54 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP, IF
Curated Selection
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