UHRF1 antibody

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.

E3 ubiquitin-protein ligase UHRF1|Inverted CCAAT box-binding protein of 90 kDa|Nuclear protein 95|Nuclear zinc finger protein Np95 (HuNp95, hNp95)|RING finger protein 106|RING-type E3 ubiquitin transferase UHRF1|Transcription factor ICBP90|Ubiquitin-like PHD and RING finger domain-containing protein 1 (hUHRF1)|Ubiquitin-like-containing PHD and RING finger domains protein 1|UHRF1|ICBP90|NP95|RNF106