UBXN1 antibody
Product Specifications
Background
Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.
Synonyms
UBX domain-containing protein 1|SAPK substrate protein 1|UBA/UBX 33.3 kDa protein|UBXN1|SAKS1
Gene ID
51035
UniProt
Q04323
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
UBX domain protein 1
Target
UBXN1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
45 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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