UBR2 antibody
Product Specifications
Background
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Synonyms
E3 ubiquitin-protein ligase UBR2|N-recognin-2|RING-type E3 ubiquitin transferase UBR2|Ubiquitin-protein ligase E3-alpha-2|Ubiquitin-protein ligase E3-alpha-II|UBR2|C6orf133|KIAA0349
Gene ID
23304
UniProt
Q8IWV8
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Ubiquitin protein ligase E3 component n-recognin 2
Target
UBR2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC
Field of Research
Epigenetics, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IF:1:10-1:100; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
66 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC
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