UBE2O antibody

E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950) . Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138) . Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153) . Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950) . Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853) .

(E3-independent) E2 ubiquitin-conjugating enzyme|E2/E3 hybrid ubiquitin-protein ligase UBE2O|Ubiquitin carrier protein O|Ubiquitin-conjugating enzyme E2 O|Ubiquitin-conjugating enzyme E2 of 230 kDa (Ubiquitin-conjugating enzyme E2-230K) |Ubiquitin-protein ligase O|UBE2O|KIAA1734