UBE2C antibody
Product Specifications
Background
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Synonyms
Ubiquitin-conjugating enzyme E2 C| (E3-independent) E2 ubiquitin-conjugating enzyme C|E2 ubiquitin-conjugating enzyme C|UbcH10|Ubiquitin carrier protein C|Ubiquitin-protein ligase C|UBE2C|UBCH10
Gene ID
11065
UniProt
O00762
Host
Mouse
Reactivity
Human
Immunogen
Ubiquitin-conjugating enzyme E2C
Target
UBE2C
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, IF, IHC, WB
Field of Research
Epigenetics, Metabolism
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
17 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
7E3
Tested Applications
ELISA, IF, IHC, WB
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