UBASH3A-Specific antibody

UBASH3A gene encodes ubiquitin-associated and SH3 domain-containing protein A (UBASH3A) also known as T-cell ubiquitin ligand 1 (TULA1) which is one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. UBASH3A gene expression is limited to only a few tissues, with its highest expression in spleen, peripheral blood leukocytes, and bone marrow. UBASH3A protein is associated with c-Cbl and ubiquitylated proteins and has been implicated in the regulation of signaling mediated by protein-tyrosine kinases oth family members can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apoptosis in T cells via its interaction with apoptosis-inducing factor (AIF) . This antibody is UBASH3A-specific.

Ubiquitin-associated and SH3 domain-containing protein A|Cbl-interacting protein 4 (CLIP4) |Suppressor of T-cell receptor signaling 2 (STS-2) |T-cell ubiquitin ligand 1 (TULA-1) |UBASH3A|STS2