TXNDC5 antibody
Product Specifications
Background
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene.
Synonyms
Thioredoxin domain-containing protein 5|Endoplasmic reticulum resident protein 46 (ER protein 46, ERp46)|Thioredoxin-like protein p46|TXNDC5|TLP46
Gene ID
81567
UniProt
Q8NBS9
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
thioredoxin domain containing 5 (endoplasmic reticulum)
Target
TXNDC5
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Storage Conditions
PBS with 0.1% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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