FR-146687
FR-146687 (FK 687) is a selective and orally active 5α-reductase inhibitor with IC50s of 1.7 nM and 4.6 nM for rat and human 5α-reductases, respectively. FR-146687 shows no inhibitory effects on other steroid oxidoreductases[1].
Product Specifications
CAS Number
146939-64-2
Product Name Alternative
FK 687; TF 505
UNSPSC
12352005
Target
5 alpha Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/fr-146687.html
Smiles
O=C(O)CCCC1=CC(C(C2=CC=C(O[C@H](C3=CC=C(CC(C)C)C=C3)CCC)C=C2)=O)=C4C=CC=CN14
Molecular Formula
C33H37NO4
Molecular Weight
511.65
References & Citations
[1]O Nakayama, et al. FR146687, a novel steroid 5 alpha-reductase inhibitor: in vitro and in vivo effects on prostates. Prostate. 1997 Jun 1;31 (4) :241-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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