TDP2 antibody
Product Specifications
Background
TTRAP is a 5-prime tyrosyl-DNA phosphodiesterase that is required for efficient repair of topoisomerase II-induced DNA double-strand breaks. Thus it can remove lots of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, generating a free 5' phosphate to DNA. It also has 3'-tyrosyl DNA phophodiesterase activity, but not so efficient as TDP1. TTRAP functions as a negative regulator of ETS1 and inhibit nuclear factor-kappa-B activation.
Synonyms
Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2, hTDP2) |5'-tyrosyl-DNA phosphodiesterase (5'-Tyr-DNA phosphodiesterase) |ETS1-associated protein 2|ETS1-associated protein II (EAPII) |TRAF and TNF receptor-associated protein|Tyrosyl-RNA phosphodiesterase|VPg unlinkase|TDP2|EAP2|TTRAP
UniProt
O95551
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
TRAF and TNF receptor associated protein
Target
TDP2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
44 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP
Frequently Asked Questions
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