NKX2-1 antibody

NKX2-1, also named as NKX2A, TITF1 and TTF1, belongs to the NK-2 homeobox family. It is a transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. NKX2-1 is crucial in the maintenance of the thyroid differentiation phenotype. It may play a role in lung development and surfactant homeostasis. Defects in NKX2-1 are the cause of benign hereditary chorea (BHC), choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD) . The antibody is specific to NKX2-1.

Homeobox protein Nkx-2.1|Homeobox protein NK-2 homolog A|Thyroid nuclear factor 1|Thyroid transcription factor 1 (TTF-1) |Thyroid-specific enhancer-binding protein (T/EBP) |NKX2-1|NKX2A|TITF1|TTF1