TRPV6 antibody
Product Specifications
Background
Calcium selective cation channel that mediates Ca (2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980) . Important for normal Ca (2+) ion homeostasis in the body, including bone and skin (By similarity) . The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369) . Inactivation includes both a rapid Ca (2+) -dependent and a slower Ca (2+) -calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg (2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Synonyms
Transient receptor potential cation channel subfamily V member 6 (TrpV6) |CaT-like (CaT-L) |Calcium transport protein 1 (CaT1) |Epithelial calcium channel 2 (ECaC2) |TRPV6|ECAC2
Gene ID
55503
UniProt
Q9H1D0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Transient receptor potential cation channel, subfamily V, member 6
Target
TRPV6
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IF, WB, IP
Field of Research
Cancer
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:1000; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
82 kDa, 70 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IF, WB, IP
Frequently Asked Questions
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