TRPV4 antibody

Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040) . Also activated by heat, low pH, citrate and phorbol esters (PubMed:18826956, PubMed:18695040) . Increase of intracellular Ca (2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956) . Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity) . Acts as a regulator of intracellular Ca (2+) in synoviocytes (PubMed:19759329) . Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329) . Together with PKD2, forms mechano-and thermosensitive channels in cilium (PubMed:18695040) . Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity) . Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity) . Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity) .

Transient receptor potential cation channel subfamily V member 4 (TrpV4) |Osm-9-like TRP channel 4 (OTRPC4) |Transient receptor potential protein 12 (TRP12) |Vanilloid receptor-like channel 2|Vanilloid receptor-like protein 2 (VRL-2) |Vanilloid receptor-related osmotically-activated channel (VR-OAC) |TRPV4|VRL2|VROAC