TRPC4AP antibody
Product Specifications
Background
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX (TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca (2+) storage reduction in response to CHRM1.
Synonyms
Short transient receptor potential channel 4-associated protein (Trp4-associated protein, Trpc4-associated protein) |Protein TAP1|TNF-receptor ubiquitous scaffolding/signaling protein (Protein TRUSS) |TRPC4AP|C20orf188|TRRP4AP
Gene ID
26133
UniProt
Q8TEL6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Transient receptor potential cation channel, subfamily C, member 4 associated protein
Target
TRPC4AP
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IP, IHC, WB
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
91 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IP, IHC, WB
Curated Selection
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