TRIM33 antibody
Product Specifications
Background
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor(By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade(Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).
Synonyms
E3 ubiquitin-protein ligase TRIM33|Ectodermin homolog|RET-fused gene 7 protein (Protein Rfg7)|RING-type E3 ubiquitin transferase TRIM33|Transcription intermediary factor 1-gamma (TIF1-gamma)|Tripartite motif-containing protein 33|TRIM33|KIAA1113|RFG7|TIF1G
Gene ID
51592
UniProt
Q9UPN9
Host
Rabbit
Reactivity
Human
Immunogen
tripartite motif-containing 33
Target
TRIM33
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
140-150 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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