TRIM33 antibody

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity) . Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade) .

E3 ubiquitin-protein ligase TRIM33|Ectodermin homolog|RET-fused gene 7 protein (Protein Rfg7) |RING-type E3 ubiquitin transferase TRIM33|Transcription intermediary factor 1-gamma (TIF1-gamma) |Tripartite motif-containing protein 33|TRIM33|KIAA1113|RFG7|TIF1G