TRIB3 antibody
Product Specifications
Background
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.
Synonyms
Tribbles homolog 3 (TRB-3) |Neuronal cell death-inducible putative kinase|SINK|p65-interacting inhibitor of NF-kappa-B|TRIB3|C20orf97|NIPK|SKIP3|TRB3
Gene ID
57761
UniProt
Q96RU7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Tribbles homolog 3 (Drosophila)
Target
TRIB3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IP
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
42 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IP
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