TNFSF13B antibody

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands-2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.

Tumor necrosis factor ligand superfamily member 13B|B lymphocyte stimulator (BLyS) |B-cell-activating factor|BAFF|Dendritic cell-derived TNF-like molecule|TNF- and APOL-related leukocyte expressed ligand 1 (TALL-1) |Tumor necrosis factor ligand superfamily member 13b, membrane form|Tumor necrosis factor ligand superfamily member 13b, soluble form|TNFSF13B|BAFF|BLYS|TALL1|TNFSF20|ZTNF4