TNFRSF1A antibody
Product Specifications
Background
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Synonyms
Tumor necrosis factor receptor superfamily member 1A|Tumor necrosis factor receptor 1 (TNF-R1) |Tumor necrosis factor receptor type I (TNF-RI, TNFR-I) |p55|p60|Tumor necrosis factor receptor superfamily member 1A, membrane form|Tumor necrosis factor-binding protein 1 (TBPI) |TNFRSF1A|TNFAR|TNFR1
UniProt
P19438
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Tumor necrosis factor receptor superfamily, member 1A
Target
TNFRSF1A
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC, FC
Field of Research
Immunology, Cardiovascular, Developmental biology, Signal Transduction
Purification
Protein A+G purification
Dilution
WB: 1:500-1:5000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
1G4
Tested Applications
ELISA, WB, IHC, FC
Immunogen Sequence
250-455aa, cytoplasmic
Curated Selection
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