TNFRSF1A antibody

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

Tumor necrosis factor receptor superfamily member 1A|Tumor necrosis factor receptor 1 (TNF-R1) |Tumor necrosis factor receptor type I (TNF-RI, TNFR-I) |p55|p60|Tumor necrosis factor receptor superfamily member 1A, membrane form|Tumor necrosis factor-binding protein 1 (TBPI) |TNFRSF1A|TNFAR|TNFR1