TICAM2 antibody
Product Specifications
Background
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.
Synonyms
TIR domain-containing adapter molecule 2 (TICAM-2)|Putative NF-kappa-B-activating protein 502|TRIF-related adapter molecule|Toll-like receptor adaptor protein 3|Toll/interleukin-1 receptor domain-containing protein (MyD88-4)|TICAM2|TIRAP3|TIRP|TRAM
Gene ID
353376
UniProt
Q86XR7
Host
Rabbit
Reactivity
Human
Immunogen
toll-like receptor adaptor molecule 2
Target
TICAM2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Immunology, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
32 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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