THOC7 antibody
Product Specifications
Background
Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex(EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.
The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus(KSHV) intronless mRNAs and infectious virus production.
Synonyms
THO complex subunit 7 homolog|Functional spliceosome-associated protein 24 (fSAP24)|Ngg1-interacting factor 3-like protein 1-binding protein 1 (NIF3L1-binding protein 1)|hTREX30|THOC7|NIF3L1BP1
Gene ID
80145
UniProt
Q6I9Y2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
THO complex 7 homolog(Drosophila)
Target
THOC7
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
24 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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