TCHP antibody
Product Specifications
Background
Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (PubMed:15731013, PubMed:18931701) . Is a negative regulator of ciliogenesis (PubMed:25270598) .
Synonyms
Trichoplein keratin filament-binding protein (Protein TCHP) |Mitochondrial protein with oncostatic activity (Mitostatin) |Tumor suppressor protein|TCHP
Gene ID
84260
UniProt
Q9BT92
Host
Rabbit
Reactivity
Human
Immunogen
Trichoplein, keratin filament binding
Target
TCHP
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Cancer
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
61 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
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