TBC1D17 antibody
Product Specifications
Background
Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC) . Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known.
Synonyms
TBC1 domain family member 17|TBC1D17
Gene ID
79735
UniProt
Q9HA65
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
TBC1 domain family, member 17
Target
TBC1D17
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF, IHC
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
73-100 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF, IHC
Immunogen Sequence
1-350aa
Curated Selection
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