SYNGAP1 antibody
Product Specifications
Background
Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity) .
Synonyms
Ras/Rap GTPase-activating protein SynGAP|Neuronal RasGAP|Synaptic Ras GTPase-activating protein 1 (Synaptic Ras-GAP 1) |SYNGAP1|KIAA1938
Gene ID
8831
UniProt
Q96PV0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synaptic Ras GTPase activating protein 1 homolog (rat)
Target
SYNGAP1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IF
Field of Research
Neuroscience, Cardiovascular, Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
148 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IF
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