SUPT16H antibody
Product Specifications
Background
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II) .
Synonyms
FACT complex subunit SPT16|Chromatin-specific transcription elongation factor 140 kDa subunit|FACT 140 kDa subunit|FACTp140|Facilitates chromatin transcription complex subunit SPT16 (hSPT16) |SUPT16H|FACT140|FACTP140
Gene ID
6830
UniProt
Q9Y5B9
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Suppressor of Ty 16 homolog
Target
SUPT16H
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
140 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP
Curated Selection
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