STK24 antibody

Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2(MAPK8 and MAPK9), p38(MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Serine/threonine-protein kinase 24|Mammalian STE20-like protein kinase 3 (MST-3)|STE20-like kinase MST3|Serine/threonine-protein kinase 24 36 kDa subunit Alternative names: Mammalian STE20-like protein kinase 3 N-terminal (MST3/N)|Serine/threonine-protein kinase 24 12 kDa subunit Alternative names: Mammalian STE20-like protein kinase 3 C-terminal (MST3/C)|STK24|MST3|STK3