STIM1 antibody
Product Specifications
Background
Plays a role in mediating store-operated Ca (2+) entry (SOCE), a Ca (2+) influx following depletion of intracellular Ca (2+) stores (By similarity) . Acts as Ca (2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca (2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca (2+) release-activated Ca (2+) (CRAC) channel subunit ORAI1 (PubMed:16208375) . Involved in enamel formation (By similarity) . Activated following interaction with TMEM110/STIMATE, leading to promote STIM1 conformational switch (By similarity) .
Synonyms
Stromal interaction molecule 1|STIM1|GOK
Gene ID
6786
UniProt
Q13586
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Stromal interaction molecule 1
Target
STIM1
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Immunology
Purification
Protein A+G purification
Dilution
WB: 1:200-1:2000 IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
77 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
4G6
Tested Applications
ELISA, WB, IHC
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