SOX2 antibody

Product Specifications

Background

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity) . Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity) . Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) .

Synonyms

Transcription factor SOX-2|SOX2

Gene ID

6657

UniProt

P48431

Host

Rabbit

Reactivity

Human, Mouse, Rat, Zebrafish

Immunogen

SRY (sex determining region Y) -box 2

Target

SOX2

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, IF, WB, IHC

Field of Research

Neuroscience, Stem Cells, Metabolism, Epigenetics

Purification

Immunogen affinity purified

Dilution

WB: 1:2000-1:20000; IHC: 1:50-1:200; IF: 1:50-1:500

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

34 kDa

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, IF, WB, IHC

Immunogen Sequence

129-317aa

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