SOX2 antibody
Product Specifications
Background
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity) . Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity) . Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) .
Synonyms
Transcription factor SOX-2|SOX2
Gene ID
6657
UniProt
P48431
Host
Rabbit
Reactivity
Human, Mouse, Rat, Zebrafish
Immunogen
SRY (sex determining region Y) -box 2
Target
SOX2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IF, WB, IHC
Field of Research
Neuroscience, Stem Cells, Metabolism, Epigenetics
Purification
Immunogen affinity purified
Dilution
WB: 1:2000-1:20000; IHC: 1:50-1:200; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
34 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IF, WB, IHC
Immunogen Sequence
129-317aa
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