SOCS6 antibody
Product Specifications
Background
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins(By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
Synonyms
Suppressor of cytokine signaling 6 (SOCS-6)|Cytokine-inducible SH2 protein 4 (CIS-4)|Suppressor of cytokine signaling 4 (SOCS-4)|SOCS6|CIS4|SOCS4
Gene ID
9306
UniProt
O14544
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
suppressor of cytokine signaling 6
Target
SOCS6
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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