SOCS3 antibody
Product Specifications
Background
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity) . Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity) .
Synonyms
Suppressor of cytokine signaling 3 (SOCS-3) |Cytokine-inducible SH2 protein 3 (CIS-3) |STAT-induced STAT inhibitor 3 (SSI-3) |SOCS3|CIS3|SSI3
Gene ID
9021
UniProt
O14543
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Suppressor of cytokine signaling 3
Target
SOCS3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IF, IP
Field of Research
Signal Transduction, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
30 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB, IF, IP
Curated Selection
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