SMURF1 antibody
Product Specifications
Background
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Plays a role in dendrite formation by melanocytes (PubMed:23999003) .
Synonyms
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) |HECT-type E3 ubiquitin transferase SMURF1|SMAD ubiquitination regulatory factor 1|SMAD-specific E3 ubiquitin-protein ligase 1|SMURF1|KIAA1625
Gene ID
57154
UniProt
Q9HCE7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
SMAD specific E3 ubiquitin protein ligase 1
Target
SMURF1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Epigenetics, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
83-90 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
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