TNKS 22
TNKS 22 (compound 22) is an orally active and selective tankyrase inhibitor. TNKS 22 inhibits TNKS1 and TNKS2 with IC50s of 0.1 and 4.1 nM, respectively[1].
Product Specifications
CAS Number
1507362-00-6
Product Name Alternative
TNKS-IN-22
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tnks-22.html
Smiles
O=C1C2=CC=CC=C2NC(SCCC(N[C@@H]3CC[C@@H](C4=NN=C(C5=CC=CC=C5)O4)CC3)=O)=N1
Molecular Formula
C25H25N5O3S
Molecular Weight
475.56
References & Citations
[1]Hua Z, et al. Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors. J Med Chem. 2013 Dec 27;56 (24) :10003-15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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